Crystallization from Supersaturated Solutions: Role of Lecithin and Composite Simulated Intestinal Fluid

被引:0
作者
Anura S. Indulkar
Yi Gao
Shweta A. Raina
Geoff G. Z. Zhang
Lynne S. Taylor
机构
[1] Purdue University,Department of Industrial and Physical Pharmacy, College of Pharmacy
[2] AbbVie Inc.,Drug Product Development, Research and Development
[3] AbbVie Inc.,Science & Technology (S&T), Operations
来源
Pharmaceutical Research | 2018年 / 35卷
关键词
biorelevant media; crystallization; nucleation; simulated intestinal fluids; supersaturation;
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[1]  
Newman A(2012)Assessing the performance of amorphous solid dispersions J Pharm Sci 101 1355-1377
[2]  
Knipp G(2012)The use of amorphous solid dispersions: a formulation strategy to overcome poor solubility and dissolution rate Drug Discov Today Technol 9 e79-e85
[3]  
Zografi G(2012)Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems Mol Pharm 9 2063-2079
[4]  
Van den Mooter G(2013)Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway Pharm Res 30 2976-2992
[5]  
Anby MU(2016)Supersaturation potential of salt, co-crystal, and amorphous forms of a model weak base Cryst Growth Des 16 737-748
[6]  
Williams HD(2007)In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: illustration of intraluminal supersaturation Int J Pharm 336 302-309
[7]  
McIntosh M(2010)Predicting intestinal precipitation—a case example for a basic BCS class II drug Pharm Res 27 2119-2130
[8]  
Benameur H(2011)Precipitation in and supersaturation of contents of the upper small intestine after Administration of two Weak Bases to fasted adults Pharm Res 28 3145-3158
[9]  
Edwards GA(2016)Supersaturation and precipitation of Posaconazole upon entry in the upper small intestine in humans J Pharm Sci 105 2677-2684
[10]  
Pouton CW(2015)Impact of solubilizing additives on supersaturation and membrane transport of drugs Pharm Res 32 3350-3364