Polyhydroxyalkanoic acids from structurally-unrelated carbon sources in Escherichia coli

被引：0
作者：
Qian Wang
Qianqian Zhuang
Quanfeng Liang
Qingsheng Qi
机构：
[1] Shandong University,National Glycoengineering Research Center, State Key Laboratory of Microbial Technology
来源：
Applied Microbiology and Biotechnology | 2013年 / 97卷
关键词：
Polyhydroxyalkanoates; Unrelated carbon source; PHA; Metabolic engineering;
D O I：
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学科分类号：
摘要：
Polyhydroxyalkanoates (PHAs) that contain varied monomers with different chain lengths/structures were normally synthesized when a structurally-related precursor was present. The biosynthesis of PHAs from unrelated carbon sources in microorganisms including Escherichia coli met many challenges in the past. Recently, with the development of metabolic engineering and synthetic biology, the production of PHAs from unrelated carbon sources obtained a breakthrough. Polyesters containing 2-hydroxypropionate, 3-hydroxypropionate, 4-hydroxybutyrate, 3-hydroxyvalarate, and medium-chain-length 3-hydroxyalkanoate monomers can all be synthesized in E. coli by integrating exogenous or endogenous pathways and/or genes. This review will summarize the progresses in this area. In addition, the strategies that lead to the production of PHAs with varied monomers and high polymer content in the cell are discussed.
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页码：3301 / 3307
页数：6
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