Adjuvant use of e-aminocaproic acid (Amicar) in the endovascular treatment of cranial arteriovenous fistulae

被引:0
作者
D. F. Kallmes
W. F. Marx
M. E. Jensen
H. J. Cloft
H. M. Do
G. Lanzino
K. West
J. E. Dion
机构
[1] Department of Radiology,
[2] Box 170,undefined
[3] University of Virginia Health Sciences Center,undefined
[4] Charlottesville,undefined
[5] VA 22908,undefined
[6] USA e-mail: wfm8p@virginia.edu,undefined
[7] Tel.: + 1-8 04-9 24 97 19,undefined
[8] Fax: + 1-8 04-9 82 16 18,undefined
[9] Department of Radiology,undefined
[10] Emory University,undefined
[11] Atlanta,undefined
[12] Georgia,undefined
[13] USA,undefined
[14] Department of Neurological Surgery,undefined
[15] University of Virginia Health Sciences Center,undefined
[16] Charlottesville,undefined
[17] Virginia,undefined
[18] USA,undefined
[19] Department of Pharmacy,undefined
[20] University of Virginia Health Sciences Center,undefined
[21] Charlottesville,undefined
[22] Virginia,undefined
[23] USA,undefined
来源
Neuroradiology | 2000年 / 42卷
关键词
Endovascular Treatment; Cavernous Fistula; Aminocaproic Acid; Dural Arteriovenous Fistula; EACA;
D O I
暂无
中图分类号
学科分类号
摘要
We report our experience with the use of the antifibrinolytic agent ɛ -aminocaproic acid (EACA), Amicar, as an adjuvant to endovascular treatment of cranial arteriovenous fistulae. We also review applications of antifibrinolytic agents to neurovascular disorders and discuss the mechanism of action, dosing strategy, contraindications, and possible complications associated with the use of EACA. We identified 13 patients with cranial arteriovenous fistulae (five direct carotid cavernous fistulae [CCF], seven dural arteriovenous fistulae [DAVF], and one vein of Galen malformation) who received EACA as an adjunct to endovascular treatment. In all cases embolic coils were the primary embolic agent. We reviewed the modes of initial endovascular therapy and angiographic findings immediately thereafter and the response to EACA. Two direct CCF and two DAVF were completely thrombosed on follow-up angiography, and two DAVF demonstrated diminished flow after EACA therapy. Seven fistulae did not respond to EACA. Four of eight tightly coiled fistulae thrombosed, while none of five loosely coiled fistulae thrombosed. None of four cases with a residual fistula separate from the coil mass underwent thrombosis with EACA, while four of nine cases without a separate fistula thrombosed. There was no morbidity related to EACA therapy. EACA may thus be useful as an adjunct to endovascular treatment of cranial arteriovenous fistulae. Loose or incomplete coil packing of the fistula predicts a poor response to EACA therapy.
引用
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页码:302 / 308
页数:6
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