The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis

被引：0
作者：
Siyin Guo
Jing Huang
Genpeng Li
Wenjie Chen
Zhihui Li
Jianyong Lei
机构：
[1] Sichuan University,Division of Thyroid Surgery, Department of General Surgery, West China Hospital
来源：
Molecular Cancer | / 22卷
关键词：
Liquid biopsy; Extracellular vesicles; Circulating tumor cells; Tumor metastasis; Pre-metastatic niche; Biomarkers;
D O I：
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学科分类号：
摘要：
Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely related in the process of distant tumor metastasis. Primary tumors are shed and released into the bloodstream to form CTCs that are referred to as seeds to colonize and grow in soil-like distant target organs, while EVs of tumor and nontumor origin act as fertilizers in the process of tumor metastasis. There is no previous text that provides a comprehensive review of the role of EVs on CTCs during tumor metastasis. In this paper, we reviewed the mechanisms of EVs on CTCs during tumor metastasis, including the ability of EVs to enhance the shedding of CTCs, protect CTCs in circulation and determine the direction of CTC metastasis, thus affecting the distant metastasis of tumors.
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