Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

被引：0
作者：
Adriana Vieira-de-Abreu
Robert A. Campbell
Andrew S. Weyrich
Guy A. Zimmerman
机构：
[1] University of Utah School of Medicine,Department of Medicine
[2] University of Utah School of Medicine,Program in Molecular Medicine
[3] Instituto Oswaldo Cruz,Labrotorio de Immunofarmacologia
来源：
Seminars in Immunopathology | 2012年 / 34卷
关键词：
Platelets; Inflammation; Innate immunity; Adaptive immunity; Infection; Host defense;
D O I：
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学科分类号：
摘要：
Platelets are chief effector cells in hemostasis. In addition, however, their specializations include activities and intercellular interactions that make them key effectors in inflammation and in the continuum of innate and adaptive immunity. This review focuses on the immune features of human platelets and platelets from experimental animals and on interactions between inflammatory, immune, and hemostatic activities of these anucleate but complex and versatile cells. The experimental findings and evidence for physiologic immune functions include previously unrecognized biologic characteristics of platelets and are paralleled by new evidence for unique roles of platelets in inflammatory, immune, and thrombotic diseases.
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页码：5 / 30
页数：25
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  • [1] Coller BS(2008)The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend Blood 112 3011-3025
  • [2] Shattil SJ(2003)The evolving role of platelets in inflammation J Thromb Haemost 1 1897-1905
  • [3] Weyrich AS(2004)Platelets: signaling cells in the immune continuum Trends Immunol 25 489-495
  • [4] Lindemann S(2010)Regulation of adaptive immunity by the innate immune system Science 327 291-295
  • [5] Zimmerman GA(2007)Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation J Immunol 178 6017-6022
  • [6] Weyrich AS(2007)Evolving functions of endothelial cells in inflammation Nat Rev Immunol 7 803-815
  • [7] Zimmerman GA(2008)Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function Arterioscler Thromb Vasc Biol 28 s17-s24
  • [8] Iwasaki A(2010)Immunology. Arsonists in rheumatoid arthritis Science 327 528-529
  • [9] Medzhitov R(2007)Dynamic visualization of thrombopoiesis within bone marrow Science 317 1767-1770
  • [10] Danese S(2009)A HaemAtlas: characterizing gene expression in differentiated human blood cells Blood 113 e1-e9
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