Anti-cancer potential of gold complexes

被引：151

作者：

Tiekink E.R.T. ^{[1
]}

机构：

[1] Department of Chemistry, University of Texas at San Antonio, San Antonio

来源：

Inflammopharmacology | 2008年 / 16卷 / 3期

关键词：

Anti-cancer; Anti-HIV; Anti-malarial; Anti-proliferative; Anti-tumor; Cytotoxicity; Gold; Gold compounds;

D O I：

10.1007/s10787-007-0018-5

中图分类号：

学科分类号：

摘要：

A full range of gold compounds is currently being investigated for their potential as anti-tumor agents. Gold(I) compounds related to the anti-arthritic drug Auranofin® continue to attract attention, especially those carrying biologically active molecules with anti-tumor activity in their own right. Tetrahedrally coordinated gold(I) compounds, that possibly target mitochondria, are under development with a particular focus upon moderating their hydrophilicity. A resurgence of interest in square-planar gold(III) compounds has occurred in the last decade. A wide variety of species: mono- and di-nuclear, neutral and charged, coordination and organometallic, etc. are being developed. Supporting many investigations are studies of mechanistic aspects of gold compounds but a clear understanding of the mechanism of action of these compounds has yet to be delineated. © 2008 Springer.

引用

页码：138 / 142

页数：4

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