Initial experience with a prototype dual-crystal (LSO/NaI) dual-head coincidence camera in oncology

被引:0
作者
Urvi Joshi
Otto S. Hoekstra
Ronald Boellaard
Emile F. I. Comans
Pieter G. H. M. Raijmakers
Rik J. Pijpers
Steven D. Miller
Gerrit J. J. Teule
Arthur van Lingen
机构
[1] VU University Medical Centre,Department of Nuclear Medicine
[2] VU University Medical Centre,Department of Clinical Epidemiology and Biostatistics
[3] CTI PET Systems (CPS),undefined
来源
European Journal of Nuclear Medicine and Molecular Imaging | 2004年 / 31卷
关键词
Dual-head coincidence; Lutetium oxyorthosilicate; Positron emission tomography; Fluorodeoxyglucose;
D O I
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摘要
The aim of this study was to evaluate the in vivo performance of a prototype dual-crystal [lutetium oxyorthosilicate (LSO)/sodium iodide (NaI)] dual-head coincidence camera (DHC) for PET and SPET (LSO-PS), in comparison to BGO-PET with fluorine-18 fluorodeoxyglucose (FDG) in oncology. This follows earlier reports that LSO-PS has noise-equivalent counting (NEC) rates comparable to partial ring BGO-PET, i.e. clearly higher than standard NaI DHCs. Twenty-four randomly selected oncological patients referred for whole-body FDG-PET underwent BGO-PET followed by LSO-PS. Four nuclear medicine physicians were randomised to read a single scan modality, in terms of lesion intensity, location and likelihood of malignancy. BGO-PET was considered the gold standard. Forty-eight lesions were classified as positive with BGO-PET, of which LSO-PS identified 73% (95% CI 60–86%). There was good observer agreement for both modalities in terms of intensity, location and interpretation. Lesions were missed by LSO-PS in 13 patients in the chest (n=6), neck (n=3) and abdomen (n=4). The diameter of these lesions was estimated to be 0.5–1 cm. Initial results justify further evaluation of LSO-PS in specific clinical situations, especially if a role as an instrument of triage for PET is foreseen.
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页码:596 / 598
页数:2
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