Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer

被引:0
作者
Lu Yang
Arup Bhattacharya
Yun Li
Sandra Sexton
Xiang Ling
Fengzhi Li
Yuesheng Zhang
机构
[1] Department of Pharmacology and Therapeutics,Department of Pharmacology and Toxicology, and Massey Cancer Center
[2] Roswell Park Comprehensive Cancer Center,undefined
[3] Virginia Commonwealth University School of Medicine,undefined
[4] Department of Urology,undefined
[5] Roswell Park Comprehensive Cancer Center,undefined
[6] Department of Animal Resources,undefined
[7] Roswell Park Comprehensive Cancer Center,undefined
来源
Journal of Experimental & Clinical Cancer Research | / 41卷
关键词
Aderbasib; Cetuximab; Colorectal cancer; EGFR; HER2; Panitumumab; PEPD; Therapeutic resistance;
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[1]  
Spano JP(2005)Impact of EGFR expression on colorectal cancer patient prognosis and survival Ann Oncol 16 102-108
[2]  
Lagorce C(2005)Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study Mod Pathol 18 1350-1356
[3]  
Atlan D(2017)Epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer Cochrane Database Syst Rev 6 337-345
[4]  
Milano G(2004)Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer N Engl J Med 351 1658-1664
[5]  
Domont J(2007)Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer J Clin Oncol 25 569-579
[6]  
Benamouzig R(2014)Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study Lancet Oncol. 15 1254-1261
[7]  
Shia J(2010)Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer J Clin Oncol 28 1084-1094
[8]  
Klimstra DS(2014)Acquired resistance to EGFR-targeted therapies in colorectal cancer Mol Oncol 8 1044-1057
[9]  
Li AR(2020)Prevalence of RAS and BRAF mutations in metastatic colorectal cancer patients by tumor sidedness: a systematic review and meta-analysis Cancer Med 9 1269-1280
[10]  
Qin J(2014)Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution Cancer Discov 4 1757-1765