Dyslipoproteinemia during the active course of systemic lupus erythematosus in association with anti-double-stranded DNA (anti-dsDNA) antibodies

被引:0
作者
Sara Kashef
Mohammad Mehdi Ghaedian
Akbar Rajaee
Abbas Ghaderi
机构
[1] Shiraz University of Medical Sciences,Department of Pediatrics, Division of Immunology and Allergy, Allergy Research Center
[2] Shiraz University of Medical Sciences,Department of Internal Medicine, Division of Rheumatology
[3] Shiraz University of Medical Sciences,Department of Immunology, Shiraz Medical School
[4] Shiraz University of Medical Sciences,undefined
来源
Rheumatology International | 2007年 / 27卷
关键词
SLE; Dyslipoproteinemia; Anti-double-stranded DNA antibody;
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摘要
Dyslipoproteinemia is common in lupus patients. In this study, we investigated the pattern of dyslipoproteinemia in the course of active systemic lupus erythematosus (SLE) in possible association with anti-double-stranded DNA (anti-dsDNA) antibodies. Forty-six lupus patients under 45 years old who fulfilled the American College of Rheumatology revised criteria for the classification of SLE were selected. The exclusion criteria were renal failure, nephrotic syndrome, thyroid or liver disease, diabetes mellitus, obesity, pregnancy and taking drugs that induce dyslipidemia. Disease activity was measured by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Comparison of the lipid profiles, between active and inactive groups determined high levels of serum TG and VLDL and low levels of serum HDL in active group in comparison with inactive group(P < 0.05). The results indicated that the levels of TG and VLDL were significantly elevated in the patients with positive anti-dsDNA (P < 0.05). Although, the mean of serum HDL levels was also lower in patients with positive anti-dsDNA, the difference was not significant. This pattern of dyslipoproteinemia in active SLE may be associated with the autoimmune mechanisms especially in relation to the presence of anti-dsDNA antibodies.
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页码:235 / 241
页数:6
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