Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction

被引：0

作者：

Shuang Zhang

Alexandre Paccalet

David Rohde

Sebastian Cremer

Maarten Hulsmans

I-Hsiu Lee

Kyle Mentkowski

Jana Grune

Maximilian J. Schloss

Lisa Honold

Yoshiko Iwamoto

Yi Zheng

Miriam A. Bredella

Colleen Buckless

Brian Ghoshhajra

Vikas Thondapu

Anja M. van der Laan

Jan J. Piek

Hans W. M. Niessen

Fabio Pallante

Raimondo Carnevale

Sara Perrotta

Daniela Carnevale

Oriol Iborra-Egea

Christian Muñoz-Guijosa

Carolina Galvez-Monton

Antoni Bayes-Genis

Charles Vidoudez

Sunia A. Trauger

David T. Scadden

Filip K. Swirski

Michael A. Moskowitz

Kamila Naxerova

Matthias Nahrendorf

机构：

[1] Center for Systems Biology,Department of Radiology

[2] Massachusetts General Hospital and Harvard Medical School,Department of Cardiology

[3] Massachusetts General Hospital and Harvard Medical School,Department of Pathology and Cardiac Surgery

[4] Heart Center,Department of AngioCardioNeurology and Translational Medicine

[5] Amsterdam Cardiovascular Sciences,Department of Molecular Medicine

[6] Amsterdam UMC,Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology

[7] University of Amsterdam,Department of Internal Medicine I

[8] Amsterdam Cardiovascular Sciences,undefined

[9] Amsterdam UMC,undefined

[10] VU Medical Center,undefined

[11] I.R.C.C.S. INM Neuromed,undefined

[12] Sapienza University of Rome,undefined

[13] Institut del Cor Germans Trias i Pujol,undefined

[14] Harvard Center for Mass Spectrometry,undefined

[15] Harvard University,undefined

[16] Harvard University,undefined

[17] Cardiovascular Research Institute,undefined

[18] Icahn School of Medicine at Mount Sinai,undefined

[19] Cardiovascular Research Center,undefined

[20] Massachusetts General Hospital and Harvard Medical School,undefined

[21] University Hospital Würzburg,undefined

来源：

Nature Cardiovascular Research | 2023年 / 2卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Because the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell homeostasis, metabolic cues may influence emergency myelopoiesis. Here we show, in humans and female mice, that hematopoietic progenitor cells increase fatty acid metabolism after MI. Blockade of fatty acid oxidation by deleting carnitine palmitoyltransferase (Cpt1a) in hematopoietic cells of Vav1Cre/+Cpt1afl/fl mice limited hematopoietic progenitor proliferation and myeloid cell expansion after MI. We also observed reduced bone marrow adiposity in humans, pigs and mice after MI. Inhibiting lipolysis in adipocytes using AdipoqCreERT2Atglfl/fl mice or local depletion of bone marrow adipocytes in AdipoqCreERT2iDTR mice also curbed emergency hematopoiesis. Furthermore, systemic and regional sympathectomy prevented bone marrow adipocyte shrinkage after MI. These data establish a critical role for fatty acid metabolism in post-MI emergency hematopoiesis.

引用

页码：1277 / 1290

页数：13

共 50 条

[1] Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction
Zhang, Shuang
Paccalet, Alexandre
Rohde, David
Cremer, Sebastian
Hulsmans, Maarten
Lee, I-Hsiu
Mentkowski, Kyle
Grune, Jana
Schloss, Maximilian J.
Honold, Lisa
Iwamoto, Yoshiko
Zheng, Yi
Bredella, Miriam A.
Buckless, Colleen
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Thondapu, Vikas
van der Laan, Anja M.
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Munoz-Guijosa, Christian
Galvez-Monton, Carolina
Bayes-Genis, Antoni
Vidoudez, Charles
Trauger, Sunia A.
Scadden, David T.
Swirski, Filip K.
Moskowitz, Michael A.
Naxerova, Kamila
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