Targeting hypoxia-inducible factors: therapeutic opportunities and challenges

被引：0
作者：
Xiaoyi Yuan
Wei Ruan
Bentley Bobrow
Peter Carmeliet
Holger K. Eltzschig
机构：
[1] The University of Texas Health Science Center at Houston,Department of Anaesthesiology, Critical Care and Pain Medicine, McGovern Medical School
[2] Central South University,Department of Anaesthesiology, The Second Xiangya Hospital
[3] The University of Texas Health Science Center at Houston,Department of Emergency Medicine, McGovern Medical School
[4] KU Leuven,Laboratory of Angiogenesis & Vascular Metabolism, Center for Cancer Biology, VIB, Department of Oncology
[5] Aarhus University,Laboratory of Angiogenesis & Vascular Heterogeneity, Department of Biomedicine
[6] Khalifa University of Science and Technology,Center for Biotechnology
[7] Outcomes Research Consortium,undefined
来源：
Nature Reviews Drug Discovery | 2024年 / 23卷
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摘要：
Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and inhibition have emerged as therapeutic targets in various human diseases. Pharmacologically desirable effects of HIF activation include erythropoiesis stimulation, cellular metabolism optimization during hypoxia and adaptive responses during ischaemia and inflammation. By contrast, HIF inhibition has been explored as a therapy for various cancers, retinal neovascularization and pulmonary hypertension. This Review discusses the biochemical mechanisms that control HIF stabilization and the molecular strategies that can be exploited pharmacologically to activate or inhibit HIFs. In addition, we examine medical conditions that benefit from targeting HIFs, the potential side effects of HIF activation or inhibition and future challenges in this field.
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页码：175 / 200
页数：25
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