Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk

被引：0
作者：
Huey-Yi Chen
Ya-Wen Chung
Wei-Yong Lin
Wei-Chi Chen
Fuu-Jen Tsai
Chang-Hai Tsai
机构：
[1] China Medical University,Department of Obstetrics and Gynecology, China Medical University Hospital, School of Chinese Medicine, College of Chinese Medicine
[2] China Medical University,Department of Medical Genetics, China Medical University Hospital, College of Chinese Medicine
[3] China Medical University,Department of Urology, China Medical University Hospital, Institute of Integrated Medicine, College of Chinese Medicine
[4] National Chung Hsing University,College of Life Science
[5] Asia University,undefined
来源：
International Urogynecology Journal | 2008年 / 19卷
关键词：
Pelvic organ prolapse; Estrogen receptor α gene polymorphism; Genotype;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor α (ERα) gene polymorphisms were associated with POP risk by conducting a case-control association study in 88 women with POP and 153 women without POP. Genotypes of the ERα (ESR1) gene polymorphisms (rs17847075, rs2207647, rs2234693, rs3798577, and rs2228480) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. There was significant difference between women with and those without POP in the distribution of the ESR1 rs2228480 genotypes evaluated. By using multivariable logistic regression, age and ESR1 rs2228480 genotype GA were significantly associated with POP risk. Although the sample size of women with POP studied is small, the present study shows that ERα genotype may be associated with POP risk.
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页码：1159 / 1163
页数：4
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