Cytoadherence phenotype of Plasmodium falciparum- infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria

被引:0
作者
Talleh Almelli
Nicaise T Ndam
Sem Ezimegnon
Maroufou J Alao
Charles Ahouansou
Gratien Sagbo
Annick Amoussou
Philippe Deloron
Rachida Tahar
机构
[1] UMR 216 Mère et Enfant Face aux Infections Tropicales,Institut de Recherche pour le Développement (IRD)
[2] Université Paris Descartes,PRES Sorbonne Paris Cité
[3] Faculté de Pharmacie,Département de pédiatrie
[4] Centre d’Etude et de recherche sur le Paludisme Associé à la Grossesse et l’Enfance (CERPAGE),Service de pédiatrie
[5] Hôpital Mère-enfant de la lagune (HOMEL),Service de pédiatrie
[6] Centre National Hospitalo-Universitaire (CNHU),undefined
[7] Hôpital de zone de Suru-Léré,undefined
来源
Malaria Journal | / 13卷
关键词
Cerebral malaria; Uncomplicated malaria; genes; Domain cassette; Transcript abundance; Cytoadherence; CD36; ICAM-1; CSPG; CSA;
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  • [1] Idro R(2010)Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome Pediatr Res 68 267-274
  • [2] Marsh K(1985)Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration Am J Pathol 119 385-401
  • [3] John CC(1991)Microvascular sequestration of parasitized erythrocytes in human falciparum malaria: a pathological study Am J Trop Med Hyg 44 168-175
  • [4] Newton CR(2006)A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction Trends Parasitol 22 503-508
  • [5] MacPherson GG(1995)The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Cell 82 89-100
  • [6] Warrell MJ(1995)-infected erythrocytes Cell 82 77-87
  • [7] White NJ(2004)Cloning the J Exp Med 199 1179-1190
  • [8] Looareesuwan S(2006) gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes Infect Immun 74 3904-3911
  • [9] Warrell DA(2006) associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes Mol Biochem Parasitol 150 211-218
  • [10] Pongponratn E(2012)Differential expression of var gene groups is associated with morbidity caused by Proc Natl Acad Sci U S A 109 E1791-E1800