Effects of maternal methyl-supplement diet on hippocampal glucocorticoid receptor mRNA expression in rats selected for behavior

被引：0
作者：
Yu. E. Herbeck
I. N. Os’kina
R. G. Gulevich
I. Z. Plyusnina
机构：
[1] Institute of Cytology and Genetics,
来源：
Cytology and Genetics | 2010年 / 44卷
关键词：
Glucocorticoid Receptor; Plasma Corticosterone Level; Glucocorticoid Negative Feedback; Meth Ylation; Maternal Methyl;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the present work, we study glucocorticoid receptor (GR) gene expression in gray rats selected for aggressive and domestic behavior, as well as in offspring of mothers with methyl-supplemented diet during pregnancy. Tame selection is associated with increased GR mRNA expression as compared with aggressive rats, whereas maternal methyl-supplemented diet inhibits GR activity in tame rats. GR gene promoter methylation is an important way of altering GR expression.
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页码：108 / 113
页数：5
相关论文
共 89 条
[11]  
Gerbek Yu.E.(2005)Transgenerational Epigenetic Effects Trends Neurosci. 28 456-463
[12]  
Shikhevich Yu.E.(2005)Maternal Care As a Model for Experience-Dependent Chromatin Plasticity? J. Neurosci. 25 11045-11054
[13]  
Plyusnina I.Z.(1987)Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life Genetika 23 1011-1025
[14]  
Gulevich R.G.(2002)Neuroendocrine and Neurochemical Mechanisms of Domestication of Animals J. Nutr. 132 2393S-2400S
[15]  
Weaver I.C.(2000)Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring Mol. Endocrinol. 14 506-517
[16]  
DrAlessio A.C.(2007)5′-Heterogeneity of Glucocorticoid Receptor Messenger RNA Is Tissue Specific: Differential Regulation of Variant Transcripts by Early-Life Events World J. Biol. Psych. 8 262-268
[17]  
Brown S.E.(2007)The Glucocorticoid Receptor Gene Exon 1-F Promoter Is Not Methylated at the NGFI-A Binding Site in Human Hippocampus Br. J. Nutr. 97 1064-1073
[18]  
Hellstrom I.C.(2007)Induction of Altered Epigenetic Regulation of the Hepatic Glucocorticoid Receptor in the Offspring of Rats Fed a Protein-Restricted Diet during Pregnancy Suggests That Reduced DNA Methyltransferase-1 Expression Is Involved in Impaired DNA Methylation and Changes in Histone Modifications Rev. Endocr. Metab. Disords 8 321-330
[19]  
Dymov S.(2001)Glucocorticoid Receptor Physiology Mol. Cell. Endocrinol. 185s.1/2 61-71
[20]  
Sharma S.(2008)Glucocorticoid Programming of the Fetus; Adult Phenotypes and Molecular Mechanisms PLoS ONE 3 3475-undefined
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