Effects of maternal methyl-supplement diet on hippocampal glucocorticoid receptor mRNA expression in rats selected for behavior

被引：0
作者：
Yu. E. Herbeck
I. N. Os’kina
R. G. Gulevich
I. Z. Plyusnina
机构：
[1] Institute of Cytology and Genetics,
来源：
Cytology and Genetics | 2010年 / 44卷
关键词：
Glucocorticoid Receptor; Plasma Corticosterone Level; Glucocorticoid Negative Feedback; Meth Ylation; Maternal Methyl;
D O I：
暂无
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学科分类号：
摘要：
In the present work, we study glucocorticoid receptor (GR) gene expression in gray rats selected for aggressive and domestic behavior, as well as in offspring of mothers with methyl-supplemented diet during pregnancy. Tame selection is associated with increased GR mRNA expression as compared with aggressive rats, whereas maternal methyl-supplemented diet inhibits GR activity in tame rats. GR gene promoter methylation is an important way of altering GR expression.
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页码：108 / 113
页数：5
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