Quaternary phosphonium reversible inhibitors of cholinesterases of different animals

The quaternary phosphonium compounds were found to be reversible inhibitors of cholinesterases of different animals and showed species-specificity of action depending on their inhibitor structure. We have revealed difference in the inhibitory specificity of various acetylcholinesterase preparations. A difference has been shown in inhibitory parameters of optic ganglia of individuals of the squid Berryteuthis magister from different habitat areas. For the first time in comparing phosphonium and ammonium isologues-tetrabutyl- and tributylhexyl derivatives, it has been shown that they are agents practically similar by the character of the anticholinesterase action.