Relationship between quality of life and behavioural disorders in children with persistent asthma: a Multiple Indicators Multiple Causes (MIMIC) model

被引：0
作者：
Laura Montalbano
Giuliana Ferrante
Silvia Montella
Giovanna Cilluffo
Antonio Di Marco
Sara Bozzetto
Emanuela Di Palmo
Amelia Licari
Lucia Leonardi
Valeria Caldarelli
Michele Ghezzi
Stefania La Grutta
Franca Rusconi
机构：
[1] Institute for Research and Biomedical Innovation,National Research Council of Italy
[2] IRIB,Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialities
[3] University of Palermo,Department of Translational Medical Sciences
[4] Federico II University,Pediatric Pulmonology and Sleep & Long Term Ventilation Unit, Academic Department Pediatric Hospital “Bambino Gesù”
[5] Piazza S. Onofrio 4,Division of Emergency Medicine, Department of Women’s and Children’s Health
[6] Rome,Pediatric Unit, Department of Medical and Surgical Sciences
[7] Italy,Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo
[8] University of Padova,Department of Paediatrics
[9] University of Bologna,Pediatric Unit, Department of Obstetrics, Gynecology and Pediatrics, Azienda USL
[10] University of Pavia, IRCCS
[11] “Sapienza” University of Rome,Department of Pediatrics, Ospedale dei Bambini
[12] Azienda USL-IRCCS,Department of Mother and Child
[13] Viale Risorgimento,Department of Pediatrics, Pulmonary and Allergy Disease Pediatric Unit and Cystic Fibrosis Center
[14] 80,Department of Pediatrics and Emergency, Pediatric Allergy and Pulmunology Unit
[15] 42123,Department of Pediatrics
[16] University of Milan,Department of Pediatrics
[17] Unit of Epidemiology,Department of Surgery, Dentistry, Paediatrics and Gynaecology
[18] ‘Anna Meyer’ Children’s University Hospital,Department of Translational Medical Sciences
[19] Azienda USL-IRCCS,Department of Pediatrics
[20] Allergy Unit,Cystic Fibrosis Unit, Departmet of Pediatrics
[21] Department of Pediatrics,Department of Pediatrics, Children’s Hospital “G. Salesi”
[22] Meyer Children’s University Hospital,undefined
[23] IRCCS Istituto Giannina Gaslini,undefined
[24] Azienda Ospedaliera-Universitaria “Consorziale-Policlinico”,undefined
[25] Women’s and Children’s Health Department,undefined
[26] University of Padova,undefined
[27] Pediatric Unit,undefined
[28] Department of Mother and Child Health,undefined
[29] Salesi Children’s Hospital,undefined
[30] Pediatric Pulmonology and Sleep & Long Term Ventilation Unit,undefined
[31] Academic Department Pediatric Hospital “Bambino Gesù”,undefined
[32] University of Chieti,undefined
[33] Sapienza University,undefined
[34] Pediatric Pulmonary Unit,undefined
[35] Meyer Pediatric University Hospital,undefined
[36] Centro Pediatrico dell’Asma e della Tosse,undefined
[37] Istituti Ospedalieri Bergamaschi,undefined
[38] Ponte San Pietro,undefined
[39] Pediatric Broncho-Pneumology and Cystic Fibrosis Unit,undefined
[40] Department of Clinical and Experimental Medicine,undefined
[41] University of Catania,undefined
[42] Pediatric Clinic,undefined
[43] Department of Pediatrics,undefined
[44] Fondazione IRCCS Policlinico San Matteo,undefined
[45] University of Pavia,undefined
[46] Division of Pediatrics,undefined
[47] “F. Del Ponte” Hospital,undefined
[48] University of Insubria,undefined
[49] Allergy Unit,undefined
[50] Department of Pediatrics,undefined
来源：
Scientific Reports | / 10卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Knowledge on multiple interdependences between quality of life (QoL) and behavioural problems in relation to asthma severity and control is undetermined. The aims of the study were: (i) to assess the relationship of QoL and behavioural problems with asthma severity and control (ii) to predict children’s “abnormal/borderline” status with variation in QoL. For these purposes a multicenter case-control study on 47 Severe Asthma (SA) and 94 Moderate Asthma (MA) children was performed. The MIMIC approach was applied to investigate the effect of SA and non-controlled asthma (NC) on QoL and behavioural disorders. Logistic regression was used to estimate probabilities of having an “abnormal/borderline” status with variation in QoL. The MIMIC model showed that the magnitude of the effect of SA and NC was larger on QoL (β = −0.37 and β = −0.30, respectively) than on behavioural problems (β = 0.27). With regards to the probability of having a borderline status, in MA a QoL of 1 returned a probability of 0.81, whereas in SA a QoL of 1 returned a probability of 0.89. In conclusion, SA children are highly affected by impaired QoL and behavioural problems. The MIMIC model allowed us to obtain a comprehensive assessment of QoL and behavioural problems with asthma severity and control.
引用
收藏
相关论文
共 63 条
  • [1] Annesi-Maesano I(2013)Externalizing and internalizing behavioural problems related to asthma in school children Allergy: European Journal of Allergy and Clinical Immunology 68 1471-1474
  • [2] Escobar R(2005)Worse quality of life for children with newly diagnosed attention-deficit/hyperactivity disorder, compared with asthmatic and healthy children Pediatrics 116 e364-e369
  • [3] Brand PL(2015)Monitoring asthma in childhood: symptoms, exacerbations and quality of life European Respiratory Review 24 187-193
  • [4] Mäkelä MJ(2011)Asthma that is not well-controlled is associated with increased healthcare utilization and decreased quality of life Journal of Asthma 48 126-132
  • [5] Szefler SJ(2016)Development of a nomogram to estimate the quality of life in asthmatic children using the Childhood Asthma Control Test Pediatric Allergy and Immunology 27 514-520
  • [6] Frischer T(2016)Internalizing/externalizing problems: Review and recommendations for clinical and research applications Journal of the American Academy of Child & Adolescent Psychiatry 55 647-656
  • [7] Price D(2001)Predicting children’s quality of life in an asthma clinical trial: What do children’s reports tell us? Journal of Pediatrics 139 854-861
  • [8] Guilbert TW(2001)Behavioral adjustment in children with asthma: A meta-analysis Journal of Developmental and Behavioral Pediatrics 22 430-439
  • [9] Montalbano L(2010)An asthma-related quality of life instrument is unable to identify asthmatic children with major psychosocial problems European Journal of Pediatrics 169 1495-1501
  • [10] Achenbach TM(1992)Structural equation models in medical research Statistical methods in medical research 1 159-181
1234567