Exercise as Medicine: The Impact of Exercise Training on Nonalcoholic Fatty Liver Disease

被引：37
作者：
Audrey Thorp
Jonathan G. Stine
机构：
[1] Department of Medicine, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA
[2] Division of Gastroenterology and Hepatology, Department of Medicine, The Pennsylvania State University- Milton S. Hershey Medical Center, 500 University Drive, PO Box 850, Mail Code HU33, Hershey, 17033, PA
[3] Department of Public Health Sciences, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA
[4] Liver Center, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA
[5] Cancer Institute, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey, PA
来源：
Current Hepatology Reports | 2020年 / 19卷 / 4期
基金：
美国国家卫生研究院;
关键词：
Cardiovascular disease; Fatty liver; Lifestyle modification; Nonalcoholic steatohepatitis; Physical activity;
D O I：
10.1007/s11901-020-00543-9
中图分类号：
学科分类号：
摘要：
Purpose of Review: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of global liver disease. Because current pharmacologic treatments are ineffective, lifestyle change centered on exercise remains the most effective NAFLD treatment. The aim of this systematic review is to summarize and evaluate the current evidence supporting the use of exercise training as a medical treatment for adult patients with NAFLD. Recent Findings: At least 150 min each week of moderate intensity exercise of any type can improve NAFLD, both with and without modest weight loss. Exercise training reduces hepatic steatosis and liver inflammation, favorably changes body composition, improves vascular endothelial function, increases cardiorespiratory fitness, and can lead to histologic response. To date, exercise-based NAFLD trials are limited by small sample size and significant heterogeneity. Summary: While several key questions remain unanswered, exercise training will always be an important part of the medical management of patients with NAFLD. © Springer Science+Business Media, LLC, part of Springer Nature 2020.
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收藏
页码：402 / 411
页数：9
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