A randomised double-blind placebo-controlled 12- week feasibility trial of methotrexate added to treatment as usual in early schizophrenia: study protocol for a randomised controlled trial

[1] Cronstein BN(2005)Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis Pharmacol Rev 57 163-72

[2] Ravi Rajagopalan PT(2002)Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics Proc Natl Acad Sci 99 13481-6

[3] Zhang Z(2005)The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules Clin Immunol 114 154-63

[4] McCourt L(2006)The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure Am Heart J 151 62-8

[5] Dwyer M(2012)Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations? Brain Behav Immun 26 1273-9

[6] Benkovic SJ(2012)Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment J Psychopharmacol 26 1185-93

[7] Hammes G(2008)Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review Biol Psychiatry 63 801-8

[8] Johnston A(2012)Cytokines in schizophrenia: possible role of anti-inflammatory medications in clinical and preclinical stages Psychiatry Clin Neurosci 66 247-60

[9] Gudjonsson JE(2011)Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects Biol Psychiatry 70 663-71

[10] Sigmundsdottir H(2008)Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia J Neurosci 28 13957-66

[1] Cronstein BN(2005)Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis Pharmacol Rev 57 163-72

[2] Ravi Rajagopalan PT(2002)Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics Proc Natl Acad Sci 99 13481-6

[3] Zhang Z(2005)The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules Clin Immunol 114 154-63

[4] McCourt L(2006)The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure Am Heart J 151 62-8

[5] Dwyer M(2012)Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations? Brain Behav Immun 26 1273-9

[6] Benkovic SJ(2012)Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment J Psychopharmacol 26 1185-93

[7] Hammes G(2008)Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review Biol Psychiatry 63 801-8

[8] Johnston A(2012)Cytokines in schizophrenia: possible role of anti-inflammatory medications in clinical and preclinical stages Psychiatry Clin Neurosci 66 247-60

[9] Gudjonsson JE(2011)Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects Biol Psychiatry 70 663-71

[10] Sigmundsdottir H(2008)Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia J Neurosci 28 13957-66