Heparin-induced thrombocytopenia: present and future

被引：0
作者：
Adam Cuker
机构：
[1] University of Pennsylvania,Department of Medicine
[2] University of Pennsylvania,Department of Pathology and Laboratory Medicine
[3] Penn Comprehensive Hemophilia and Thrombosis Program,undefined
来源：
Journal of Thrombosis and Thrombolysis | 2011年 / 31卷
关键词：
Heparin-induced thrombocytopenia; HIT; Epidemiology; Pathophysiology; Diagnosis; Management;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Heparin-induced thrombocytopenia (HIT) is a prothrombotic and potentially devastating complication of heparin therapy due to formation of platelet-activating antibodies against complexes of platelet factor 4 and heparin. Over the last several decades, great advances in our understanding of HIT have elevated a once enigmatic syndrome, the mere existence of which was doubted by the medical community, to a well-characterized disorder. Nevertheless, critical questions remain unanswered. The objective of this review is to examine our current understanding of the epidemiology, pathophysiology, diagnosis, and management of HIT and to highlight areas of future inquiry.
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页码：353 / 366
页数：13
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