Microbial response to acid stress: mechanisms and applications

被引：0
作者：
Ningzi Guan
Long Liu
机构：
[1] East China Normal University,Synthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences
[2] Jiangnan University,Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education
来源：
Applied Microbiology and Biotechnology | 2020年 / 104卷
关键词：
Acid stress; Resistance mechanism; Probiotics; Organic acids; Systems and synthetic biology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Microorganisms encounter acid stress during multiple bioprocesses. Microbial species have therefore developed a variety of resistance mechanisms. The damage caused by acidic environments is mitigated through the maintenance of pH homeostasis, cell membrane integrity and fluidity, metabolic regulation, and macromolecule repair. The acid tolerance mechanisms can be used to protect probiotics against gastric acids during the process of food intake, and can enhance the biosynthesis of organic acids. The combination of systems and synthetic biology technologies offers new and wide prospects for the industrial applications of microbial acid tolerance mechanisms. In this review, we summarize acid stress response mechanisms of microbial cells, illustrate the application of microbial acid tolerance in industry, and prospect the introduction of systems and synthetic biology to further explore the acid tolerance mechanisms and construct a microbial cell factory for valuable chemicals.
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页码：51 / 65
页数：14
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