Synthesis and cytotoxic activity of trinitromethyl derivatives of 1,3,5-triazine

被引：0
|
作者：
Bakharev V.V. [1 ]
Gidaspov A.A. [1 ]
Yakunina N.G. [2 ]
Bulychev Yu.N. [2 ]
机构：
[1] Samara State Technical University, Samara
[2] Science Research Institute of Experimental Tumor Diagnosis and Treatment, N. N. Blokhin Russian Oncological Scientific Center, Russian Academy of Medical Sciences, Moscow
来源：
Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 5期
关键词：
Cytotoxic Activity; Triazine; Human Tumor Cell Line; Compound VIII; Cyanuric Chloride;
D O I：
10.1007/s11094-008-0101-2
中图分类号：
学科分类号：
摘要：
New trinitromethyl derivatives of 1,3,5-triazine were synthesized with different substituents in positions 2 and 4. Data on the in vitro cytotoxic activity of the resulting compounds were obtained using a panel of 60 human tumor cell lines. The most active compounds were the 2,4-diamino-and 2-dimethylamino-4-azido derivatives. In terms of the general level of cytotoxicity, compounds of this series were more active than previously studied polynitromethyl derivatives of 1,3,5-triazine. © 2008 Springer Science+Business Media, Inc.
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页码：241 / 244
页数：3
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