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Reactive oxygen species-dependent signaling regulates cancer
被引：0
|作者：
Frank Weinberg
Navdeep S. Chandel
机构：
[1] Northwestern University Medical School,Division of Pulmonary and Critical Care Medicine, Department of Medicine
[2] Northwestern University Medical School,Department of Cell and Molecular Biology
来源：
Cellular and Molecular Life Sciences
|
2009年
/
66卷
关键词：
Mitochondria;
HIF;
ROS;
Metastasis;
Tumorigenesis;
NADPH oxidase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.
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页码：3663 / 3673
页数：10
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