The role of ADRB2 gene polymorphisms in malignancies

被引：0
|
作者：
Yaqian Wang
Shujuan Jiang
机构：
[1] Shandong University,Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine
[2] Shandong Provincial Hospital Affiliated to Shandong First Medical University,Department of Respiratory and Critical Care Medicine
[3] Shandong Key Laboratory of Infectious Respiratory Disease,undefined
来源：
Molecular Biology Reports | 2021年 / 48卷
关键词：
ADRB2; Malignancy; Single nucleotide polymorphism; β; -Adrenergic receptor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, clinical prognosis and treatment resistance in malignancies. Polymorphisms of the ADRB2 gene have been confirmed to be associated with transcriptional activity, mRNA translation, and beta-2-adrenergic receptor expression and sensitivity. This review discusses clinically relevant examples of single nucleotide polymorphisms of ADRB2 in malignancies and the effects of these polymorphisms on cancer susceptibility, prognosis and treatment response of cancer patients.
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收藏
页码：2741 / 2749
页数：8
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