Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

被引：0
|
作者：
Bolan Linghu
Evan S Snitkin
Zhenjun Hu
Yu Xia
Charles DeLisi
机构：
[1] Boston University,Bioinformatics Program
[2] Boston University,Department of Chemistry
来源：
Genome Biology | / 10卷
关键词：
Disease Gene; Additional Data File; Seed Gene; Candidate Disease Gene; Disease Pair;
D O I：
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学科分类号：
摘要：
We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are supported by epidemiology, but with no previous genetic basis. Such associations can drive novel hypotheses on molecular mechanisms of diseases and therapies.
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