Chemotactic responses of osteoblastic MC3T3-E1 cells toward zinc chloride

被引：0
作者：
Sanae Kanno
C. D. Anuradha
Seishiro Hirano
机构：
[1] National Institute for Environmental Studies,Research Center for Environmental Risk
来源：
Biological Trace Element Research | 2001年 / 83卷
关键词：
Zinc; MC3T3-E1; chemotaxis; bone renewal; G-protein; calcium; platelet-derived growth factor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although zinc (Zn) is known to participate in bone formation, its exact role in the remodeling of this tissue has not been fully clarified. The present study was designed to investigate whether Zn has a role at the resorptive sites in vitro. We investigated the migration of osteoblastic MC3T3-E1 cells in response to Zn using a Boyden chamber assay. Exposure of MC3T3-E1 cells to Zn stimulated the migration of MC3T3-E1 cells. Checkerboard analysis revealed that the migration of MC3T3-E1 cells toward Zn was a directional (chemotaxis) rather than a random (chemokinesis) motion.
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页码：49 / 55
页数：6
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