Probabilistic Regulation of IL-4 Production

被引：0
作者：
Liying Guo
Jane Hu-Li
William E. Paul
机构：
[1] National Institutes of Health,Laboratory of Immunology, National Institute of Allergy and Infectious Diseases
来源：
Journal of Clinical Immunology | 2005年 / 25卷
关键词：
Cytokines; chromatin; monoallelism; green florescence protein;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Among a population of uniformly differentiated TH2 cells, only a portion express IL-4 upon stimulation and those that do often express the product of only a single allele. We review the evidence for the basis of IL-4 monoallelism and argue that it depends upon probabilistic expression of the Il4 gene. Further, we argue that probabilistic expression may provide a powerful mechanism through which certain key functions of IL-4, such as immunoglobulin class switching and determination of macrophage phenotype, may be efficiently regulated.
引用
收藏
页码：573 / 581
页数：8
相关论文
共 153 条
[1]  
Poo WJ(1988)Receptor-directed focusing of lymphokine release by helper T cells Nature 332 378-380
[2]  
Conrad L(1998)Monoallelic expression of the interleukin-2 locus Science 279 2118-2121
[3]  
Janeway CA(1998)Mice with a fluorescent marker for interleukin 2 gene activation Immunity 9 209-216
[4]  
Hollander GA(1998)Independent and epigenetic regulation of the interleukin-4 alleles in CD4+T cells Science 281 1352-1354
[5]  
Zuklys S(1998)Regulation of IL-4 expression by activation of individual alleles Immunity 9 217-228
[6]  
Morel C(2000)Allele-specific expression patterns of interleukin-2 and Pax-5 revealed by a sensitive single-cell RT-PCR analysis Curr Biol 10 789-792
[7]  
Mizoguchi E(2003)Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones Eur J Immunol 33 2142-2148
[8]  
Mobisson K(1999)Bias in the expression of IL-4 alleles: The use of T cells from a GFP knock-in mouse Cold Spring Harb Symp Quantum Biol 64 599-602
[9]  
Simpson S(2001)Regulation of expression of IL-4 alleles: Analysis using a chimeric GFP/IL-4 gene Immunity 14 1-11
[10]  
Terhorst C(2005)Probabilistic regulation of IL-4 production in Th2 cells: Accessibility at the Il4 locus Immunity 23 89-99
12345678910