Gene polymorphism and levels of pro-inflammatory cytokines in plasma and synovial fluid of patients with posttraumatic knee osteoarthritis

被引：1

作者：

Vnukov V.V. ^{[1
]}

Krolevets I.V. ^{[2
]}

Panina S.B. ^{[1
]}

Milutina N.P. ^{[1
]}

Ananyan A.A. ^{[1
]}

Sagakyants A.B. ^{[1
]}

Zabrodin M.A. ^{[2
]}

机构：

[1] Southern Federal University, ul. B. Sadovaya 105/42, Rostov-on-Don

[2] Rostov State Medical University, Nahichevanskii per. 29, Rostov-on-Don

来源：

Advances in Gerontology | 2016年 / 6卷 / 3期

关键词：

gene polymorphism; posttraumatic knee osteoarthritis; proinflammatory cytokines; synovial fluid;

D O I：

10.1134/S2079057016030152

中图分类号：

学科分类号：

摘要：

Posttraumatic knee osteoarthritis patients (n = 117) and healthy individuals (n = 94) were investigated to determine the genotype and allelic frequency distribution of polymorphic loci Т-31С, С + 3953Т IL-1β and G-308A TNF-α. The plasma and synovial fluid levels of proinflammatory cytokines IL-1β and TNF-α were also measured in 31 patients. The study demonstrated that the plasma and synovial fluid levels of IL-1β but not TNF-α were increased in patients with posttraumatic knee osteoarthritis. Also, the linkage between TNF-α levels and polymorphic locus G-308A TNF-α was shown: the presence of allele–308А was associated with decreased TNF-α levels. It was found that polymorphic loci Т-31С, С+3953Т IL-1β, and G-308A TNF-α are not markers of predisposition to posttraumatic knee osteoarthritis in Russian population of Rostov Oblast. © 2016, Pleiades Publishing, Ltd.

引用

页码：198 / 203

页数：5

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