BAP1 and Breast Cancer Risk

被引：0
作者：
Isabelle Coupier
Pierre-Yves Cousin
David Hughes
Patricia Legoix-Né
Alexandra Trehin
Olga M. Sinilnikova
Dominique Stoppa-Lyonnet
机构：
[1] Institut Curie – Section Médicale,Service de Génétique Oncologique
[2] Institut Curie – Section Recherche,INSERM U509 Pathologie Moléculaire des Cancers
[3] Centre de Recherche International sur le Cancer,Unité d’Epidémiologie Génétique
[4] Institut Curie – Section Recherche,Laboratoire de Transfert
[5] Institut Curie,The Institut Curie
[6] Hybrigenics,Hybrigenics Projet
[7] Hospices Civils de Lyon – Centre Léon Bérard,Plate
来源：
Familial Cancer | 2005年 / 4卷
关键词：
hereditary breast cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
BAP1 whose protein interacts with BRCA1 was analysed in a series of 47 French familial breast cancer cases negatively tested for BRCA1/2 mutations. The lack of detection of deleterious mutations suggests that BAP1 is not a high risk breast cancer predisposing gene. However, a common identified variant, rs123602, may be tested in sporadic cases as candidate for moderate risk.
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页码：273 / 277
页数：4
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