Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis

被引:0
作者
J C Ralston
F Badoud
B Cattrysse
P D McNicholas
D M Mutch
机构
[1] University of Guelph,Department of Human Health and Nutritional Sciences
[2] University of Guelph,Department of Mathematics and Statistics
来源
International Journal of Obesity | 2014年 / 38卷
关键词
fatty acids; lipid metabolism; gas chromatography; microarray; clustering;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1449 / 1456
页数:7
相关论文
共 178 条
[1]  
Ahima RS(2013)Physiology. The health risk of obesity—better metrics imperative Science 341 856-858
[2]  
Lazar MA(2011)Bariatric surgery, adipose tissue and gut microbiota Int J Obes (Lond) 35 S7-S15
[3]  
Clement K(2011)Adipose tissue remodeling and obesity J Clin Invest 121 2094-2101
[4]  
Sun K(1999)Molecular regulation of adipocyte differentiation Semin Cell Dev Biol 10 3-10
[5]  
Kusminski CM(2008)Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity Diabetes 57 3247-3257
[6]  
Scherer PE(2008)Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism Curr Opin Lipidol 19 248-256
[7]  
Cowherd RM(2009)Biochemical and physiological function of stearoyl-CoA desaturase Am J Physiol Endocrinol Metab 297 E28-E37
[8]  
Lyle RE(1992)Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes Genes Dev 6 533-544
[9]  
McGehee RE(2006)Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acidsin triglyceride synthesis J Lipid Res 47 1928-1939
[10]  
Ledoux S(2010)Role of fatty acid elongases in determination of J Lipid Res 51 1871-1877