Quality of life in adult patients after bone marrow transplantation

被引：2

作者：

Yano K. ^{[1
]}

Yazaki M. ^{[2
]}

Kitaori K. ^{[3
]}

Hirabayashi N. ^{[4
]}

Minami S. ^{[5
]}

Morishita Y. ^{[6
]}

Yamada H. ^{[7
]}

Naoe T. ^{[8
]}

Kojima H. ^{[9
]}

Goto S.-I. ^{[4
]}

Kodera Y. ^{[5
]}

Morishima Y. ^{[3
]}

机构：

[1] Department of Infectious Diseases, Hamamatsu Medical Center, 328 Tomitsuka

[2] Department of Pediatrics, Nagoya City Univ. Medical School, Nagoya

[3] Department of Internal Medicine, Meitetsu Hospital, Nagoya

[4] Department of Internal Medicine, Nagoya Second Red Cross Hospital, Nagoya

[5] Department of Internal Medicine, Japan. Red Cross Nagoya First Hosp., Nagoya

[6] Department of Internal Medicine, Kohnan Showa Hospital, Kohnan

[7] Department of Internal Medicine, Nagoya Ekisaikai Hospital, Nagoya

[8] Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Nagoya

[9] Department of Internal Medicine, Fujita Health University, Toyoake

来源：

International Journal of Clinical Oncology | 1998年 / 3卷 / 3期

关键词：

Adjustment; BMT; Quality of life;

D O I：

10.1007/BF02489908

中图分类号：

学科分类号：

摘要：

Background: Since culture, history, personal financial situation, and the health insurance system are strongly associated with quality of life (QOL) for patients undergoing continuing medical care, any investigation into this subject should be done within individual areas and countries. Patients and Methods: We investigated QOL in adult survivors after bone marrow transplantation (BMT), by administering a mail-back questionnaire to outpatients seen at 8 hospitals, in association with Nagoya BMT groups. Results: The respondents surveyed were aged 20 years and older at the time of this study, and were not in life-threatening relapse. The underlying diseases were chronic myelogenous leukemia, acute myelogenous leukemia, acute lymphoblastic leukemia, malignant lymphoma, severe aplastic anemia, and myelodysplastic syndrome. The average age at the time of study was 37.6 years, and the median interval between transplantation and the time of study was 38.2 months. Eighty-four patients were treated with allogeneic BMT, 4 with autologous transplants, and 1 with a syngeneic transplant. Conclusion: Our data showed that QOL gradually continued to improve over time, even 5 years after transplantation. We found that the older a patient was at the time of BMT or at the time he or she responded to the questionnaire, the poorer his or her QOL was. Total body irradiation as a part of preconditioning, a diagnosis of acute graft-versus-host disease (GVHD), and underlying disease were unrelated to QOL. Longer length of time since transplantation positively affects QOL, while diagnosis of chronic GVHD negatively affects QOL. Being of female sex and being of greater age were factors associated with a greater risk of job loss.

引用

页码：152 / 158

页数：6

共 14 条

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