Cryo-EM structure of a metazoan separase–securin complex at near-atomic resolution

被引:0
作者
Andreas Boland
Thomas G Martin
Ziguo Zhang
Jing Yang
Xiao-chen Bai
Leifu Chang
Sjors H W Scheres
David Barford
机构
[1] MRC Laboratory of Molecular Biology,
来源
Nature Structural & Molecular Biology | 2017年 / 24卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Cryo-EM analyses provide a near-atomic view of the C. elegans securin–separase complex, with insights into the mechanism by which securin inhibits separase's protease activity.
引用
收藏
页码:414 / 418
页数:4
相关论文
共 150 条
  • [1] Uhlmann F(2000)Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast Cell 103 375-386
  • [2] Wernic D(2000)Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase Cell 103 399-410
  • [3] Poupart MA(2001)Cohesin cleavage by separase required for anaphase and cytokinesis in human cells Science 293 1320-1323
  • [4] Koonin EV(2015)Short- and long-term effects of chromosome mis-segregation and aneuploidy Nat. Rev. Mol. Cell Biol. 16 473-485
  • [5] Nasmyth K(2017)Time to split up: dynamics of chromosome separation Trends Cell Biol. 27 42-54
  • [6] Waizenegger IC(1998)An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast Cell 93 1067-1076
  • [7] Hauf S(1999)Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1 Nature 400 37-42
  • [8] Meinke A(1999)Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis Science 285 418-422
  • [9] Peters JM(2005)Human full-length securin is a natively unfolded protein Protein Sci. 14 1410-1418
  • [10] Hauf S(2008)Structural and dynamic characterization of intrinsically disordered human securin by NMR spectroscopy J. Am. Chem. Soc. 130 16873-16879