Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

被引:0
作者
Jun Song
Yeping Huang
Wenjian Zheng
Jing Yan
Min Cheng
Ruxing Zhao
Li Chen
Cheng Hu
Weiping Jia
机构
[1] Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases
[2] Qilu Hospital of Shandong University,Department of Endocrinology
[3] Tongji University School of Medicine,Department of Endocrinology, Shanghai East Hospital
[4] Qingdao Haici Medical Treatment Group,Department of Geriatrics
[5] Huangdao Disease Prevention and Control Center,undefined
来源
Frontiers of Medicine | 2018年 / 12卷
关键词
resveratrol; reactive oxygen species; AMPK; mTOR; autophagy;
D O I
暂无
中图分类号
学科分类号
摘要
Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular mechanisms. We found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells. Resveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROS reduction. Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway. Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway. Thus, the induction of autophagy by resveratrol may provide a novel therapeutic candidate for cardioprotection in metabolic syndrome.
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页码:697 / 706
页数:9
相关论文
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