Modeling the effect of the cephalic phase of insulin secretion on glucose metabolism

被引:0
作者
Amparo Güemes
Pau Herrero
Jorge Bondia
Pantelis Georgiou
机构
[1] Imperial College London,Centre for Bio
[2] Universitat Politècnica de València,Inspired Technology, Department of Electrical and Electronic Engineering
[3] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM),Instituto Universitario de Automática e Informática Industrial
来源
Medical & Biological Engineering & Computing | 2019年 / 57卷
关键词
Cephalic phase; Neural modeling; Insulin secretion; Vagus nerve; Metabolic modeling;
D O I
暂无
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学科分类号
摘要
The nervous system has a significant impact in glucose homeostasis and endocrine pancreatic secretion in humans, especially during the cephalic phase of insulin release (CPIR); that is, before a meal is absorbed. However, the underlying mechanisms of this neural-pancreatic interaction are not well understood and therefore often neglected, despite their significance to achieving an optimal glucose control. As a result, the dynamics of insulin release from the pancreas are currently described by mathematical models that reproduce the behavior of the β cells using exclusively glucose levels and other hormones as inputs. To bridge this gap, we have combined, for the first time, metabolic and neural mathematical models in a unified system to reproduce to a great extent the ideal glucoregulation observed in healthy subjects. Our results satisfactorily replicate the CPIR and its impact during the post-absorptive phase. Furthermore, the proposed model gives insight into the physiological interaction between the brain and the pancreas in healthy people and suggests the potential of considering the neural information for restoring glucose control in people with diabetes.
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页码:1173 / 1186
页数:13
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