Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects

被引：0
|
作者：
Heedoo Yoo
Timo Iirola
Sanna Vilo
Tuula Manner
Riku Aantaa
Maria Lahtinen
Mika Scheinin
Klaus T. Olkkola
William J. Jusko
机构：
[1] State University of New York at Buffalo,Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 404 Kapoor Hall
[2] University of Turku and Turku University Hospital,Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine
[3] University of Turku and Unit of Clinical Pharmacology,Department of Pharmacology, Drug Development and Therapeutics
[4] University of Helsinki and Helsinki University Hospital,Department of Anaesthesiology, Intensive Care and Pain Medicine
来源：
European Journal of Clinical Pharmacology | 2015年 / 71卷
关键词：
Dexmedetomidine; Mechanism-based modeling; Population pharmacokinetics; Pharmacodynamics; α; -adrenoceptor agonist; Norepinephrine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1197 / 1207
页数：10
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