Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects

被引：0

作者：

Heedoo Yoo

Timo Iirola

Sanna Vilo

Tuula Manner

Riku Aantaa

Maria Lahtinen

Mika Scheinin

Klaus T. Olkkola

William J. Jusko

机构：

[1] State University of New York at Buffalo,Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 404 Kapoor Hall

[2] University of Turku and Turku University Hospital,Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine

[3] University of Turku and Unit of Clinical Pharmacology,Department of Pharmacology, Drug Development and Therapeutics

[4] University of Helsinki and Helsinki University Hospital,Department of Anaesthesiology, Intensive Care and Pain Medicine

来源：

European Journal of Clinical Pharmacology | 2015年 / 71卷

关键词：

Dexmedetomidine; Mechanism-based modeling; Population pharmacokinetics; Pharmacodynamics; α; -adrenoceptor agonist; Norepinephrine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：1197 / 1207

页数：10

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