Prevalence and risk factors associated with lymphatic filariasis in American Samoa after mass drug administration

被引：25

作者：

Coutts S.P. ^{[1
]}

King J.D. ^{[2
]}

Pa'au M. ^{[3
]}

Fuimaono S. ^{[3
]}

Roth J. ^{[4
]}

King M.R. ^{[5
]}

Lammie P.J. ^{[6
]}

Lau C.L. ^{[7
]}

Graves P.M. ^{[8
]}

机构：

[1] James Cook University, College of Public Health, Medical and Veterinary Sciences, Cairns

[2] World Health Organization, Department of Control of Neglected Tropical Diseases, Geneva

[3] American Samoa Department of Health, Pago Pago

[4] Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response, Atlanta

[5] Independent Nursing Consultant, Geneva

[6] The Task Force for Global Health, Neglected Tropical Diseases Support Center, Atlanta

[7] Australian National University, Department of Global Health, Research School of Population Health, ACT

[8] James Cook University, Australian Institute of Tropical Health and Medicine and College of Public Health, Medical and Veterinary Sciences, Cairns

来源：

Tropical Medicine and Health | / 45卷 / 1期

基金：

英国医学研究理事会;

关键词：

American Samoa; Epidemiology; Lymphatic filariasis; MDA; PacELF; Prevalence; Wuchereria bancrofti;

D O I：

10.1186/s41182-017-0063-8

中图分类号：

学科分类号：

摘要：

Background: In 2000, American Samoa had 16.5% prevalence of lymphatic filariasis (LF) antigenemia. Annual mass drug administration (MDA) was conducted using single-dose albendazole plus diethylcarbamazine from 2000 to 2006. This study presents the results of a 2007 population-based PacELF C-survey in all ages and compares the adult filarial antigenemia results of this survey to those of a subsequent 2010 survey in adults with the aim of improving understanding of LF transmission after MDA. Results: The 2007 C-survey used simple random sampling of households from a geolocated list. In 2007, the overall LF antigen prevalence by immunochromatographic card test (ICT) for all ages was 2.29% (95% CI 1.66-3.07). Microfilaremia prevalence was 0.27% (95% CI 0.09-0.62). Increasing age (OR 1.04 per year, 95% CI 1.02-1.05) was significantly associated with ICT positivity on multivariate analysis, while having ever taking MDA was protective (OR 0.39, 95% CI 0.16-0.96). The 2010 survey used a similar spatial sampling design. The overall adult filarial antigenemia prevalence remained relatively stable between the surveys at 3.32% (95% CI 2.44-4.51) by ICT in 2007 and 3.23 (95% CI 2.21-4.69) by Og4C3 antigen in 2010. However, there were changes in village-level prevalence. Eight village/village groupings had antigen-positive individuals identified in 2007 but not in 2010, while three villages/village groupings that had no antigen-positive individuals identified in 2007 had positive individuals identified in 2010. Conclusions: After 7 years of MDA, with four rounds achieving effective coverage, a representative household survey in 2007 showed a decline in prevalence from 16.5 to 2.3% in all ages. However, lack of further decline in adult prevalence by 2010 and fluctuation at the village level showed that overall antigenemia prevalence at a broader scale may not provide an accurate reflection of ongoing transmission at the village level. © 2017 The Author(s).

引用

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