Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior

被引:0
|
作者
Wataru Ota
Yusuke Nakane
Makiko Kashio
Yoshiro Suzuki
Kazuhiro Nakamura
Yasuo Mori
Makoto Tominaga
Takashi Yoshimura
机构
[1] Nagoya University,Institute of Transformative Bio
[2] Furo-cho,Molecules (WPI
[3] Chikusa-ku,ITbM)
[4] Graduate School of Bioagricultural Sciences,Laboratory of Animal Integrative Physiology
[5] Nagoya University,Avian Bioscience Research Center
[6] Furo-cho,Department of Physiology
[7] Chikusa-ku,Division of Cell Signaling
[8] Graduate School of Bioagricultural Sciences,Thermal Biology Group
[9] Nagoya University,Department of Integrative Physiology
[10] Furo-cho,Department of Synthetic Chemistry and Biological Chemistry
[11] Chikusa-ku,Division of Seasonal Biology
[12] Aichi Medical University,undefined
[13] National Institute for Physiological Sciences,undefined
[14] National Institutes of Natural Sciences,undefined
[15] Exploratory Research Center on Life and Living Systems,undefined
[16] National Institutes of Natural Sciences,undefined
[17] Nagoya University Graduate School of Medicine,undefined
[18] Graduate School of Engineering,undefined
[19] Kyoto University,undefined
[20] Nishikyo-ku,undefined
[21] National Institute for Basic Biology,undefined
[22] National Institutes of Natural Sciences,undefined
来源
Scientific Reports | / 9卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Masking is a direct behavioral response to environmental changes and plays an important role in the temporal distribution of activity. However, the mechanisms responsible for masking remain unclear. Here we identify thermosensors and a possible neural circuit regulating temperature-dependent masking behavior in mice. Analysis of mice lacking thermosensitive transient receptor potential (TRP) channels (Trpv1/3/4 and Trpm2/8) reveals that temperature-dependent masking is impaired in Trpm2- and Trpm8-null mice. Several brain regions are activated during temperature-dependent masking, including the preoptic area (POA), known as the thermoregulatory center, the suprachiasmatic nucleus (SCN), which is the primary circadian pacemaker, the paraventricular nucleus of the thalamus (PVT), and the nucleus accumbens (NAc). The POA, SCN, PVT are interconnected, and the PVT sends dense projections to the NAc, a key brain region involved in wheel-running activity. Partial chemical lesion of the PVT attenuates masking, suggesting the involvement of the PVT in temperature-dependent masking behavior.
引用
收藏
相关论文
共 50 条
  • [41] The involvement of TRPM2 channel in insulin secretion and the development of diabetes
    Uchida, Kunitoshi
    Yamazaki, Jun
    Tominaga, Makoto
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2017, 133 (03) : S77 - S77
  • [42] Warm feelings for TRPM2
    Voets, Thomas
    CELL RESEARCH, 2016, 26 (11) : 1174 - 1175
  • [43] Warm feelings for TRPM2
    Thomas Voets
    Cell Research, 2016, 26 : 1174 - 1175
  • [44] TRPM2 and warmth sensation
    Tan, Chun-Hsiang
    McNaughton, Peter A.
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2018, 470 (05): : 787 - 798
  • [45] Role of basic residues in the voltage-dependent gating properties of TRPM4 and TRPM8 channels
    Talavera, K
    Voets, T
    Janssens, A
    Owsianik, G
    Vennekens, R
    Droogmans, G
    Nilius, B
    BIOPHYSICAL JOURNAL, 2005, 88 (01) : 113A - 113A
  • [46] Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells
    Bidaux, Gabriel
    Borowiec, Anne-Sophie
    Dubois, Charlotte
    Delcourt, Philippe
    Schulz, Celine
    Vanden Abeele, Fabien
    Lepage, Gilbert
    Desruelles, Emilie
    Bokhobza, Alexandre
    Dewailly, Etienne
    Slomianny, Christian
    Roudbaraki, Morad
    Heliot, Laurent
    Bonnal, Jean-Louis
    Mauroy, Brigitte
    Mariot, Pascal
    Lemonnier, Loic
    Prevarskaya, Natalia
    ONCOTARGET, 2016, 7 (20) : 29063 - 29080
  • [47] Involvement of TRPM2 in drug-resistant epilepsy through PARP-1 /TRPM2/calcineurin/ Caspase-3 pathway
    Kong, Q.
    EPILEPSIA, 2024, 65 : 444 - 444
  • [48] Isolation of Functional Temperature Activated Transmembrane Domain of Human TRPM8
    Luu, Dustin
    Chiu, Po-Lin
    Van Horn, Wade D.
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 413A - 413A
  • [49] Recent Progress in TRPM8 Modulation: An Update
    Gonzalez-Muniz, Rosario
    Angeles Bonache, M.
    Martin-Escura, Cristina
    Gomez-Monterrey, Isabel
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (11)
  • [50] Inorganic Polyphosphate Modulates TRPM8 Channels
    Zakharian, Eleonora
    Thyagarajan, Baskaran
    French, Robert J.
    Pavlov, Evgeny
    Rohacs, Tibor
    PLOS ONE, 2009, 4 (04):