Non-coding RNAs revealed during identification of genes involved in chicken immune responses

被引：0
作者：
Marie-Laure Endale Ahanda
Thomas Ruby
Håkan Wittzell
Bertrand Bed’Hom
Anne-Marie Chaussé
Veronique Morin
Anne Oudin
Catherine Chevalier
John R. Young
Rima Zoorob
机构：
[1] CNRS,Botanical museum (LD)
[2] FRE2937,undefined
[3] Lund University,undefined
[4] INRA/AgroParisTech,undefined
[5] UMR1236,undefined
[6] Génétique et Diversité Animales,undefined
[7] INRA,undefined
[8] UR1282 Infectiologie Animale et Santé Publique,undefined
[9] INSERM IFR026,undefined
[10] Plateforme Transcriptome Ouest Génopole,undefined
[11] Institute for Animal Health,undefined
[12] Compton,undefined
来源：
Immunogenetics | 2009年 / 61卷
关键词：
Non-coding RNAs; Microarray; Immune response; Chicken;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response.
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页码：55 / 70
页数：15
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