Identification of one peptide which inhibited infectivity of avian infectious bronchitis virus in vitro

被引：0
作者：
Bo Peng
Hanyang Chen
Yadi Tan
Meilin Jin
Huanchun Chen
Aizhen Guo
机构：
[1] Huazhong Agricultural University,Laboratory of Animal Virology, College of Veterinary Medicine
[2] Huazhong Agricultural University,National Key Laboratory of Agricultural Microbiology
来源：
Science in China Series C: Life Sciences | 2006年 / 49卷
关键词：
avian infectious bronchitis virus; phage display; peptides;
D O I：
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中图分类号：
学科分类号：
摘要：
Purified avian infectious bronchitis virus (IBV) was used to screen a random phage display peptide library. After the fourth panning, 10 positive phages were sequenced and characterized. The phages specifically inhibited IBV infectivity in HeLa cells and blocked IBV haemagglutination. One linear peptide “GSH HRH VHS PFV” from the positive phages with the highest neutralization titer was synthesized and this peptide inhibited IBV infection in HeLa as well. The results may contribute to development of antiviral therapeutics for IBV and studying the determinants for viral and cell interaction.
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页码：158 / 163
页数：5
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