Microglial signatures and their role in health and disease

被引：0

作者：

Oleg Butovsky

Howard L. Weiner

机构：

[1] Brigham and Women’s Hospital,Ann Romney Center for Neurologic Diseases, Department of Neurology

[2] Harvard Medical School,undefined

来源：

Nature Reviews Neuroscience | 2018年 / 19卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a unique molecular homeostatic ‘signature’, consisting of a specific transcriptional profile and surface protein expression pattern, which differs from that of tissue macrophages. In recent years, there have been a number of important advances in our understanding of the molecular signatures of homeostatic microglia and disease-associated microglia that have provided insight into how these cells are regulated in health and disease and how they contribute to the maintenance of the neural environment.

引用

页码：622 / 635

页数：13

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