Impaired tissue barriers as potential therapeutic targets for Parkinson’s disease and amyotrophic lateral sclerosis

被引:0
作者
Xin Fang
机构
[1] The First Affiliated Hospital of Nanchang University,Department of Neurology
来源
Metabolic Brain Disease | 2018年 / 33卷
关键词
Blood-brain barrier; Leaky gut; Parkinson’s disease; Barrier defects; Amyotrophic lateral sclerosis;
D O I
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学科分类号
摘要
The blood-brain barrier and the intestinal barrier show signs of disruption in patients with idiopathic Parkinson’s disease (PD) and animal models of nigrostriatal degeneration, and likewise in amyotrophic lateral sclerosis (ALS) models. A substantial body of evidence shows that defects in epithelial membrane barriers, both in the gut and within the cerebral vasculature, can result in increased vulnerability of tissues to external factors potentially participating in the pathogenesis of PD and ALS. As such, restoration of tissue barriers may prove to be a novel therapeutic target in neurodegenerative disease. In this review, we focus on the potential of new intervention strategies for rescuing and maintaining barrier functions in PD and ALS.
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页码:1031 / 1043
页数:12
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