Participation of PI3K, MAPK ERK1/2, and p38 in the Realization of Growth Potential of Mesenchymal Precursor Cells under In Vitro Conditions

被引：0
作者：
G. N. Zyuz’kov
M. G. Danilets
A. A. Ligacheva
V. V. Zhdanov
E. V. Udut
L. A. Miroshnichenko
E. V. Simanina
E. S. Trofi mova
M. Yu. Minakova
A. V. Chaikovskii
V. I. Agafonov
A. M. Dygai
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Research Institute of Pharmacology
来源：
Bulletin of Experimental Biology and Medicine | 2014年 / 156卷
关键词：
signaling pathways; PI3K; MAPK ERK1/2; p38; progenitor cells; regenerative medicine;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied the role of intracellular signal molecules PI3K, MAPK ERK1/2, and p38 in the realization of the growth potential of mesenchymal progenitor elements. Under in vitro conditions, PI3K и ERK1/2 specifi c inhibitors reduced fi broblastic colony- and cluster-formation and considerably suppressed proliferative activity of mesenchymal precursors. Blocker of p38 and protein kinase B had no effect on the function of fi broblast CFU.
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页码：556 / 559
页数：3
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