Gliomatosis cerebri type II: Two case reports

被引：0

作者：

D'Urso P.I. ^{[1
]}

D'Urso O.F. ^{[2
]}

Marsigliante S. ^{[2
]}

Storelli C. ^{[2
]}

Distante A. ^{[3
]}

Sanguedolce F. ^{[4
]}

Cimmino A. ^{[4
]}

Luzi G. ^{[5
]}

Gianfreda C.D. ^{[6
]}

Montinaro A. ^{[6
]}

Ciappetta P. ^{[1
]}

机构：

[1] Department of Neurosciences, Section of Neurosurgery, University of Bari Medical School, Bari

[2] Department of Biological and Environmental Sciences and Technologies (DiSTeBA), Ecotekne, 73100 Lecce, Via Prov.le per Monteroni

[3] CNR-IFC Lecce Section, Ecotekne, 73100 Lecce, Via Prov.le per Monteroni

[4] Department of Pathology, Section of Neuropathology, University of Bari Medical School, Bari

[5] Department of Clinical Immunology and Allergology, Sant'Anrea Hospital, Rome

[6] Neurosurgery Operative Unit, V. Fazzi Hospital

来源：

Journal of Medical Case Reports | / 3卷 / 1期

关键词：

Temozolomide; PTEN Mutation; Gliomatosis Cerebri; Signal Transduction Gene; Angiogenesis Related Gene;

D O I：

10.1186/1752-1947-0003-0000007225

中图分类号：

学科分类号：

摘要：

Introduction. Two types of gliomatosis cerebri exist: Type I and Type II. We report the results of a histological and genetic study of two cases of gliomatosis cerebri Type II, correlating these results with therapy and prognosis. Case presentation. Two patients, a 52-year-old man (Patient 1) and a 76-year-old man (Patient 2) with gliomatosis cerebri II were admitted to our institution; they underwent surgical treatment and received radiotherapy and chemotherapy. At the 24-month follow-up, Patient 1 was still alive, while Patient 2 had died. The poor prognosis of Patient 2 was underlined by molecular analysis which showed that the angiogenesis related genes VCAM1 and VEGF were overexpressed, reflecting the high degree of neovascularization. Conclusion. Genes involved in drug resistance and metallothioneins were highly expressed in Patient 2 and this, associated with unmethylated O6-methylguanine methyltransferase, can explain the lack of response to chemotherapy. © 2009 licensee BioMed Central Ltd.

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