MDM2 in breast cancer

被引：15
作者：
Masakazu Toi
Shigehira Saji
Akio Suzuki
Yutaka Yamamoto
Takeshi Tominaga
机构：
[1] Tokyo Metropolitan Komagome Hospital,Department of Surgery
来源：
Breast Cancer | 1997年 / 4卷 / 4期
关键词：
MDM2; Breast cancer; Drug resistance;
D O I：
10.1007/BF02966519
中图分类号：
学科分类号：
摘要：
TheMDM2 protein, an oncogene product, is known to act by suppressing p53 function. Although gene amplification ofMDM2 was frequently detected in human sarcomas, it was uncommon in the majority of epithelial tumors including breast cancer. However, recent reports have demonstrated that its translational activity is enhanced in a variety of carcinomas. In this report, we summarized the implications ofMDM2 overexpression in human breast cancer from the literature as well as our preliminary results.
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收藏
页码：264 / 268
页数：4
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[51]  
Lianes P(undefined)The undefined undefined undefined-undefined
[52]  
Orlow I(undefined) binding protein undefined undefined undefined-undefined
[53]  
Zhang Z-F,(undefined) gene is differentially expressed in human breast carcinoma undefined undefined undefined-undefined
[54]  
Adesina AM(undefined)Differential expression of multiple MDM2 messenger RNAs and proteins in normal and tumorigenic breast epithelial cells undefined undefined undefined-undefined
[55]  
Nalbantoglu J(undefined)The gene coding for interferon-γ is linked to the D125335 and D125313 microsatellites and to the MDM2 gene undefined undefined undefined-undefined
[56]  
Cavenee WK(undefined)Alternatively spliced mdmd2 transcripts with loss of p53 biding domain sequences; Transforming ability and frequent detection of human cancer undefined undefined undefined-undefined
[57]  
Foulkes WD(undefined)Specific P53 mutations are associated with undefined undefined undefined-undefined
[58]  
Stamp GWH(undefined) resistance to doxorubicin in breast cancer patients undefined undefined undefined-undefined
[59]  
Afzal S(undefined)Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer undefined undefined undefined-undefined
[60]  
Yamasaki I(undefined)DNA repair; Enzymatic mechanisms and relevance to drug response undefined undefined undefined-undefined
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