MDM2 in breast cancer

被引：15
作者：
Masakazu Toi
Shigehira Saji
Akio Suzuki
Yutaka Yamamoto
Takeshi Tominaga
机构：
[1] Tokyo Metropolitan Komagome Hospital,Department of Surgery
来源：
Breast Cancer | 1997年 / 4卷 / 4期
关键词：
MDM2; Breast cancer; Drug resistance;
D O I：
10.1007/BF02966519
中图分类号：
学科分类号：
摘要：
TheMDM2 protein, an oncogene product, is known to act by suppressing p53 function. Although gene amplification ofMDM2 was frequently detected in human sarcomas, it was uncommon in the majority of epithelial tumors including breast cancer. However, recent reports have demonstrated that its translational activity is enhanced in a variety of carcinomas. In this report, we summarized the implications ofMDM2 overexpression in human breast cancer from the literature as well as our preliminary results.
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页码：264 / 268
页数：4
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