Selectivity difference between carboxyethyl-β-cyclodextrin and carboxymethyl-β-cyclodextrin in enantioseparations of drugs by capillary electrophoresis

被引：0
|
作者：
Xueqin Ren
Xiaodan Su
Aijin Huang
Yiliang Sun
Zengpei Sun
机构：
[1] Peking University,Department of Chemistry
[2] National Institute for the Control of Pharmaceutical and Biological Products,undefined
来源：
Chromatographia | 2000年 / 51卷
关键词：
Capillary electrophoresis; Enantiomeric separation; Carboxyethyl-β-CD; Carboxymethyl-β-CD;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this report the separation selectivity of carboxyethyl-β-cyclodextrin (CE-β-CD) and carboxymethyl-β-cyclodextrin (CM-β-CD) for some chiral test drugs was examined. By using CE-β-CD as selector, nine out of 38 test drugs were resolved with resolutions greater than 0.9. By replacing CE-β-CD with CM-β-CD another four drugs were resolved, of which only verapamil had been previously separated with CE-β-CD. The selectivity of the two selectors differed dramatically despite their close structural resemblance.
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页码：634 / 637
页数：3
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