Malignant phyllodes tumor metastasized to the right ventricle: a case report

被引：0

作者：

Fumi Yoshidaya

Naoki Hayashi

Katsuhito Takahashi

Koyu Suzuki

Futoshi Akiyama

Mitsutomi Ishiyama

Yuko Takahashi

Atsushi Yoshida

Hiroshi Yagata

Seigo Nakamura

Hiroko Tsunoda

Hideko Yamauchi

机构：

[1] St. Luke’s International Hospital,Department of Breast Surgical Oncology

[2] Osaka Medical Center for Cancer and Cardiovascular Disease,Department of Molecular Medicine and Pathophysiology

[3] St. Luke’s International Hospital,Department of Diagnostic Pathology

[4] Cancer institute Hospital of Japanese Foundation for Cancer Research,Division of Pathology

[5] St. Luke’s International Hospital,Department of Radiology

[6] Showa University School of Medicine,Department of Breast Surgical Oncology

来源：

Surgical Case Reports | / 1卷 / 1期

关键词：

Malignant phyllodes tumor; Breast; Cardiac metastasis; Myoepithelial cells; Debulking surgery;

D O I：

10.1186/s40792-015-0121-6

中图分类号：

学科分类号：

摘要：

Cardiac metastasis of malignant phyllodes tumor is very rare. We herein report a rare case that developed cardiac metastasis from malignant phyllodes tumor. A 38-year-old woman underwent lumpectomy, and the final pathological findings showed the 5-cm malignant phyllodes tumor partially containing 1 cm of squamous cell carcinoma. Four months after the first surgery, a local recurrence of malignant phyllodes tumor and distant metastases to the bone, lung, pulmonary main trunk, and right ventricle were detected. Mass reduction surgery of cardiac metastasis of the malignant phyllodes tumor was performed to avoid sudden death. In immunohistochemical findings, the tumor was suspected to be originated in myoepithelial cells because of the expression of smooth muscle lineage including α-smooth muscle actin and Calponin1 and highly malignant characteristics showing MIB-1 and p53 highly positive with angiogenesis. Further studies are needed to clarify the effective treatment to these tumors.

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