Gender-affirming hormone therapy induces specific DNA methylation changes in blood

被引：0

作者：

Rebecca Shepherd

Ingrid Bretherton

Ken Pang

Toby Mansell

Anna Czajko

Bowon Kim

Amanda Vlahos

Jeffrey D. Zajac

Richard Saffery

Ada Cheung

Boris Novakovic

机构：

[1] Murdoch Children’s Research Institute,Molecular Immunity, Infection and Immunity Theme

[2] Royal Children’s Hospital,Department of Medicine (Austin Health)

[3] The University of Melbourne,Department of Endocrinology

[4] Austin Health,Brain and Mitochondrial Research

[5] Murdoch Children’s Research Institute,Inflammation Division

[6] Royal Children’s Hospital,Department of Adolescent Medicine

[7] The Walter and Eliza Hall Institute of Medical Research,Department of Paediatrics

[8] Royal Children’s Hospital,undefined

[9] The University of Melbourne,undefined

来源：

Clinical Epigenetics | 2022年 / 14卷

关键词：

DNA methylation; EPIC array; Transgender; Masculinization; Feminization; GAHT; Epigenetics; Gender; Immunity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 326 条

[1] Dotto G-P(2019)Gender and sex-time to bridge the gap EMBO Mol Med 11 e10668-638
[2] Klein SL(2016)Sex differences in immune responses Nat Rev Immunol 16 626-104
[3] Flanagan KL(2014)SeXX matters in immunity Trends Immunol 35 97-615
[4] Markle JG(2019)Sex and autoimmunity: proposed mechanisms of disease onset and severity Expert Rev Clin Immunol 15 607-423
[5] Fish EN(2005)Sex hormones and the immune response in humans Hum Reprod Update 11 411-492
[6] Selmi C(2012)Functions of DNA methylation: islands, start sites, gene bodies and beyond Nat Rev Genet 13 484-615
[7] Gershwin ME(2014)DNA methylation dynamics of the human preimplantation embryo Nature 511 611-1334
[8] Bouman A(2018)The key role of epigenetics in human disease prevention and mitigation N Engl J Med 378 1323-610
[9] Heineman MJ(1997)X-chromosome inactivation in mammals Annu Rev Genet 31 571-466
[10] Faas MM(2007)Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome Nat Genet 39 457-18