Association of genes involved in nicotine and tobacco smoke toxicant metabolism (CHRNA3/5, CYP2A6, and NQO1) and DNA repair (XRCC1, XRCC3, XPC, and XPA) with chronic obstructive pulmonary disease

被引：0
作者：
G. F. Korytina
L. Z. Akhmadishina
O. V. Kochetova
Yu. V. Burduk
Yu. G. Aznabaeva
Sh. Z. Zagidullin
T. V. Victorova
机构：
[1] Russian Academy of Sciences,Institute of Biochemistry and Genetics, Ufa Research Center
[2] Bashkortostan State Medical University,undefined
来源：
Molecular Biology | 2014年 / 48卷
关键词：
chronic obstructive pulmonary disease; association; gene-by-environment interaction; nicotine dependence; oxidative stress; DNA repair;
D O I：
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摘要：
Polymorphisms of the CHRNA5/A3, CYP2A6, NQO1, XPC, XRCC1, CRCC3, XPD, and XPA genes were tested for association with the development and progression of chronic obstructive pulmonary disease (COPD) in ethnic Tatars. CHRNA5 (rs16969968) (P = 0.0001, OR = 2.24) and CHRNA3 (rs1051730) (P = 0.0001, OR = 2.72) polymorphisms were associated with COPD development in the recessive model. The nondeletion variant of CYP2A6 (del) was associated with COPD risk (P = 0.00001, OR = 2.77). NQO1 (rs113341), XRCC1 (rs25487), XRCC3 (rs86539), XPC (rs2228001), and XPA (rs1800975) were associated with COPD in the additive model (P = 0.000001, OR = 2.67; P = 0.00001, OR = 0.51; P = 0.0003, OR = 1.76; P = 0.0004, OR = 0.54; and P = 0.007, OR = 0.74, respectively). A gene-by-environment interaction was observed for XPA (rs1800975) and the smoking status (Pinteract = 0.002), and the rs16969968 and rs1051730 polymorphisms of the CHRNA3/5 gene cluster showed an association with COPD only in smokers. Carriers of the CYP2A6 deletion (CYP2A6*4) had a lower smoking index (P = 0.0019). XRCC3 (rs861539) genotype TT was characterized by lower indices of pulmonary function, including vital capacity (VC) (P = 0.0487), forced vital capacity (FVC) (P = 0.0032), and forced expiratory volume in 1 second (FEV1) (P = 0.02). FVC was found to depend on the genotype at XPA (rs1800975) (P = 0.0028).
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页码：823 / 834
页数：11
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  • [11] Park MJ(2005)A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)- Eur. J. Clin. Pharmacol. 60 855-715
  • [12] Lee SW(2013)-3,5-dimethyl-2-(3-pyridyl)thiazolidin4-one hydrochloride (SM-12502) Mol. Biol. Rep. 40 5255-584
  • [13] Lee JS(2010)High prevalence of cytochrome P450 2A6*1A alleles in a black African population of Ghana Am. J. Respir. Cell Mol. Biol. 42 524-419
  • [14] Oh YM(2012)Cytochrome P450 2A6 deletion polymorphism and risk of lung cancer: A meta-analysis Free Radic. Biol. Med. 52 705-763
  • [15] Lee SD(2010)Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation Am. J. Respir. Cell Mol. Biol. 43 576-1007
  • [16] Pillai SG(2012)NAD(P)H: Quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice Am. J. Respir. Crit. Care Med. 186 412-571
  • [17] Ge D(2004)Cigarette smoke induces nucleic acid oxidation in lung fibroblasts Carcinogenesis. 25 757-556
  • [18] Zhu G(2006)Retinoic acidrelated orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema Carcinogenesis. 27 997-966
  • [19] Kong X(2010)Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA Respir. Res. 11 46-876
  • [20] Shianna KV(2009)DNA repair polymorphisms and cancer risk in non-smokers in a cohort study Am. J. Respir. Crit. Care Med. 179 566-211
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